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Can temperatures damage pills?

I have some estradiol pills, Estrance, little purple ovals. I accidentally left some in my car overnight and it got cold, pry down to like 30 F. Would cold temperatures harm the effectiveness of the pills?

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You would have to look up the chemical properties of estradiol. I'm not so sure that at 130 fahrenheit(enclosed car, very hot day) the stability can be assured. With all due respect, I would not expect a pharmacist to know the answer here.